Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | MGAM | O43451 | 3/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | SI | P14410 | 3/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194566 | 0.86 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AALDH1A1TPSAB1CCR8 | |
| SCHEMBL10144866 | 0.74 | DRD4 (0.45) | HTR1ASLC6A2SLC6A4 | |
| SCHEMBL8350065 | 0.74 | HDAC6 (0.56) | SMN1; SMN2KMT2AALDH1A1TPSAB1CCR8 | |
| SCHEMBL10194565 | 0.74 | SFRP1 (0.60) | SMN1; SMN2KMT2AALDH1A1TPSAB1DPP4 | |
| SCHEMBL14217625 | 0.70 | ALDH1A1 (0.46) | SMN1; SMN2KMT2AALDH1A1TPSAB1CCR8 | |
| SCHEMBL10194631 | 0.69 | HDAC6 (0.57) | SMN1; SMN2KMT2AALDH1A1TPSAB1DPP4 | |
| SCHEMBL10327746 | 0.67 | KMT2A (0.46) | SMN1; SMN2KMT2AALDH1A1TPSAB1CCR8 | |
| SCHEMBL10194626 | 0.67 | HDAC8 (0.50) | SMN1; SMN2KMT2AALDH1A1CCR8GAA | |
| SCHEMBL10175958 | 0.66 | HDAC3 (0.44) | HTR1A | |
| SCHEMBL14765415 | 0.66 | DRD4 (0.43) | HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485354-B1 | SULFONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-28 | — | — | EP | disclosed |