Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 9/20 | 0.33 |
| ▸ | JAK3 | P52333 | 9/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898374 | 0.85 | ADRA2A (0.47) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL12751055 | 0.85 | ADRA2A (0.47) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL12898372 | 0.85 | ADRA2A (0.47) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL12705521 | 0.74 | ADRA2A (0.48) | ADRA2AADRA2BADRA1ATAAR1ALDH1A1 | |
| SCHEMBL12828516 | 0.73 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL14197670 | 0.73 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL13498384 | 0.73 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL12872177 | 0.71 | GRM7 (0.36) | ADRA2ARIPK1 | |
| SCHEMBL4795376 | 0.70 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL4755702 | 0.70 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060301-A1 | 7-SUBSTITUTED PURINE DERIVATIVES FOR IMMUNOSUPPRESSION | PHARMACOPEIA , LLC (US) | 2008-05-22 | — | — | WO | disclosed |