Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.50 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | JAK3 | P52333 | 5/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265342 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL1266132 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL13498384 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL14197670 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL1265344 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL4755702 | 0.79 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL12828516 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL4753561 | 0.79 | ADRA2A (0.50) | ADRA2ATERTTAAR1CYP2D6ADRA2B | |
| SCHEMBL22143945 | 0.79 | ADRA2A (0.50) | ADRA2ATERTADRA2BADRA1AJAK2 | |
| SCHEMBL15818729 | 0.78 | ADRA2A (0.47) | ADRA2ATERTTAAR1CYP2D6ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874772-A1 | PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION | PHARMACOPEIA, INC. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108103-A1 | PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION | PHARMACOPEIA, INC. (US) | 2006-10-12 | — | — | WO | disclosed |