Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.37 |
| ▸ | PARG | Q86W56 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12579014 | 0.88 | HRH1 (0.40) | HRH1HTR6SCARB1PARGPIK3R1 | |
| SCHEMBL2019197 | 0.88 | HRH1 (0.40) | HRH1HTR6SCARB1PARGPIK3R1 | |
| SCHEMBL14218045 | 0.85 | SIGMAR1 (0.35) | HRH1HTR6PARGBCHEACHE | |
| SCHEMBL19015842 | 0.84 | HRH1 (0.55) | HRH1HTR6SCARB1PTGER4 | |
| SCHEMBL12579051 | 0.84 | HTR6 (0.36) | HRH1HTR6SCARB1PARGPIK3R1 | |
| SCHEMBL2023590 | 0.84 | HTR6 (0.36) | HRH1HTR6SCARB1PARGPIK3R1 | |
| SCHEMBL3144810 | 0.83 | HTR6 (0.42) | HRH1HTR6SCARB1PTGDR2DPP4 | |
| SCHEMBL12579062 | 0.83 | HRH1 (0.36) | HRH1HTR6SCARB1PARGPIK3R1 | |
| SCHEMBL14217953 | 0.82 | SCARB1 (0.49) | HRH1HTR6SCARB1 | |
| SCHEMBL12579010 | 0.82 | HRH1 (0.37) | HRH1HTR6SCARB1PARGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063867-A2 | TETRAHYDROCYCLOPENTA[B] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |