Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14218040 | 0.85 | HRH1 (0.40) | PARGHTR6BCHEACHEPTGDR2 | |
| SCHEMBL13478813 | 0.81 | HTR6 (0.50) | KDM4EMEN1KMT2AHSD17B10HTR6 | |
| SCHEMBL14218046 | 0.81 | HTR6 (0.47) | PARGHTR6PTGDR2HRH1 | |
| SCHEMBL14217955 | 0.80 | PARG (0.36) | PARGBCHEACHEPTGDR2 | |
| SCHEMBL14217996 | 0.80 | PTGDR2 (0.34) | PARGBCHEACHEPTGDR2 | |
| SCHEMBL14217956 | 0.80 | PARG (0.36) | PARGBCHEACHEPTGDR2 | |
| SCHEMBL14217937 | 0.80 | PARG (0.36) | PARGBCHEACHEPTGDR2 | |
| SCHEMBL14218082 | 0.79 | PARG (0.34) | PARGBCHEACHEPTGDR2 | |
| SCHEMBL14217938 | 0.79 | ELANE (0.34) | KDM4EALDH1A1HPGDMAPK1PARG | |
| SCHEMBL14218085 | 0.77 | HTR6 (0.40) | SIGMAR1KDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063867-A2 | TETRAHYDROCYCLOPENTA[B] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |