Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13978380 | 0.84 | RAB9A (0.67) | SMN1; SMN2NPC1RAB9AAHRMAPT | |
| SCHEMBL8262920 | 0.81 | THRB (0.48) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL19005463 | 0.77 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL13892114 | 0.76 | PLAU (0.46) | SMN1; SMN2NPC1RAB9AAHRGRM4 | |
| SCHEMBL11546092 | 0.72 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AAHRMAPT | |
| SCHEMBL10264545 | 0.71 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AAHRMAPT | |
| SCHEMBL4737237 | 0.71 | TP53 (0.45) | SMN1; SMN2MTNR1AMTNR1BALDH1A1LMNA | |
| SCHEMBL29955509 | 0.71 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AAHRMAPT | |
| SCHEMBL9504353 | 0.70 | RAB9A (0.65) | SMN1; SMN2NPC1RAB9AAHRMAPT | |
| SCHEMBL10755249 | 0.70 | NPC1 (0.74) | SMN1; SMN2NPC1RAB9AAHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008047883-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-24 | — | — | WO | disclosed |