Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869376 | 0.93 | HTR2B (0.60) | HTR2BPKMPOLBMAPTHSD17B10 | |
| SCHEMBL14218701 | 0.85 | POLB (0.62) | HTR2BPKMPOLB | |
| SCHEMBL666433 | 0.85 | PARP1 (0.60) | HTR2BPKMPOLBMAPTHSD17B10 | |
| SCHEMBL6883705 | 0.84 | PKM (0.62) | HTR2BPKMKMT2A | |
| SCHEMBL17888861 | 0.83 | HTR2B (0.62) | HTR2BPKMKMT2ACHRNA7 | |
| SCHEMBL9870915 | 0.83 | HTR2B (0.56) | HTR2BPKMPOLBMAPTHSD17B10 | |
| SCHEMBL17888844 | 0.83 | HTR2B (0.59) | HTR2BPKMPOLBMAPTHSD17B10 | |
| SCHEMBL6890364 | 0.81 | MPO (0.69) | HTR2BPOLBMAPTKMT2A | |
| SCHEMBL664921 | 0.81 | HTR2B (0.57) | HTR2BPKMPOLBKMT2ACHRNA7 | |
| SCHEMBL7533221 | 0.81 | HTR2B (0.60) | HTR2BPKMKMT2ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378411-B2 | Substituted thienopyrimidinones as a mitotic kinesin inhibitor | MERCK & CO., INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-7244723-B2 | Substituted furopyrimidinones as a mitotic kinesin inhibitors | MERCK & CO., INC. (US) | 2007-07-17 | — | — | US | disclosed |