Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550978 | 0.91 | ALDH1A1 (0.50) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL28629399 | 0.84 | ALDH1A1 (0.44) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL9169477 | 0.84 | ALDH1A1 (0.44) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL12418418 | 0.83 | ALDH1A1 (0.49) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL23296190 | 0.82 | ALDH1A1 (0.57) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL16771628 | 0.82 | ALDH1A1 (0.45) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL241884 | 0.82 | CA1 (0.52) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL156710 | 0.80 | GAA (0.46) | ALDH1A1CA12CA9CA1STAT3 | |
| SCHEMBL21408106 | 0.80 | CA12 (0.54) | ALDH1A1CA12CA9CA1CA2 | |
| SCHEMBL3969240 | 0.80 | ALDH1A1 (0.73) | ALDH1A1CA12CA9HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114059-A1 | Novel Compounds For Treatment of Cardiac Arrhythmia and Methods of Use | ARYX THERAPEUTICS, INC. | 2008-05-15 | — | — | US | disclosed |
| US-7351842-B2 | )-{3-[4-(2-Ethylamino-ethoxy)-3,5-diiodo-benzoyl]-benzofuran-2-yl}-acetic acid sec-butyl ester; amiodarone derivatives; congestive heart failure, ischemic cardiomyopathy, atrial fibrillation, ventricular tachycardia; side effect reduction: pharmacolkinetics, oral bioavailability, nontoxic | ARYX THERAPEUTICS, INC. (US) | 2008-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114059-A1 | Novel Compounds For Treatment of Cardiac Arrhythmia and Methods of Use | TNNI3, TNNT2, RYR2 | ALDH1A1 1286/4885CA12 2997/4885CA9 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.