Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219127 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1HPGDNAAAHTR7 | |
| SCHEMBL4855129 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1HPGDMLNRPOLB | |
| SCHEMBL4854195 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MLNRPOLBL3MBTL1 | |
| SCHEMBL14219125 | 0.73 | HTR2C (0.38) | SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL4861996 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1MLNRPOLBL3MBTL1 | |
| SCHEMBL27538189 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MLNRPOLBL3MBTL1 | |
| SCHEMBL14219128 | 0.69 | USP2 (0.35) | SMN1; SMN2ALDH1A1HPGDPOLBMAPT | |
| SCHEMBL11109852 | 0.66 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1HPGDNAAAHTR7 | |
| SCHEMBL4859862 | 0.66 | POLB (0.43) | SMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL8690279 | 0.65 | NAAA (0.72) | SMN1; SMN2ALDH1A1NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |