Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219649 | 0.89 | TDP1 (0.38) | TDP1MEN1KMT2APTGS2MAP2K1 | |
| SCHEMBL14220115 | 0.89 | TDP1 (0.38) | TDP1MEN1KMT2APTGS2MAP2K1 | |
| SCHEMBL14219826 | 0.89 | TDP1 (0.36) | TDP1MEN1KMT2ADHODHPTGS2 | |
| SCHEMBL14223203 | 0.89 | KDM4E (0.36) | TDP1MEN1KMT2ADHODHPTGS2 | |
| SCHEMBL14219656 | 0.89 | PTGS2 (0.41) | TDP1MEN1KMT2ADHODHPTGS2 | |
| SCHEMBL14219715 | 0.89 | PTGS2 (0.41) | TDP1MEN1KMT2ADHODHPTGS2 | |
| SCHEMBL14223201 | 0.88 | MEN1 (0.40) | TDP1MEN1KMT2ADHODHPTGS2 | |
| SCHEMBL14219832 | 0.85 | MEN1 (0.45) | TDP1MEN1KMT2ADHODHLCK | |
| SCHEMBL14220114 | 0.83 | PTGS2 (0.34) | TDP1MEN1KMT2ADHODHPTGS2 | |
| SCHEMBL14219819 | 0.81 | DHODH (0.46) | MEN1KMT2ADHODHLCKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |