Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219826 | 0.92 | TDP1 (0.36) | PTGS2DHODHEGFRIRAK4MEN1 | |
| SCHEMBL14219642 | 0.83 | TDP1 (0.39) | PTGS2DHODHEGFRIRAK4MEN1 | |
| SCHEMBL14219656 | 0.81 | PTGS2 (0.41) | PTGS2DHODHEGFRIRAK4MEN1 | |
| SCHEMBL14219649 | 0.79 | TDP1 (0.38) | PTGS2EGFRMEN1KMT2ATDP1 | |
| SCHEMBL14223203 | 0.79 | KDM4E (0.36) | PTGS2DHODHEGFRIRAK4MEN1 | |
| SCHEMBL14219718 | 0.78 | DHODH (0.36) | PTGS2DHODHEGFRMAP2K1 | |
| SCHEMBL14220128 | 0.78 | PTGS2 (0.37) | PTGS2DHODHEGFRMAP2K1 | |
| SCHEMBL14220171 | 0.77 | MEN1 (0.41) | DHODHMEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL14220172 | 0.76 | DHODH (0.35) | DHODHEGFRMEN1KMT2ATDP1 | |
| SCHEMBL14220165 | 0.76 | MAP2K1 (0.41) | DHODHEGFRMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |