Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | SMC2 | O95347 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.36 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222460 | 0.90 | MAP2K1 (0.40) | MAP2K1PTGS2MAP2K2SMC2EGFR | |
| SCHEMBL14223057 | 0.89 | MAP2K1 (0.41) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL14222454 | 0.89 | MAP2K1 (0.41) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL14220164 | 0.87 | PTGS2 (0.36) | MAP2K1PTGS2MAP2K2SMC2EGFR | |
| SCHEMBL14219660 | 0.87 | MAP2K1 (0.50) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL14219658 | 0.87 | MAP2K1 (0.39) | MAP2K1PTGS2MAP2K2SMC2EGFR | |
| SCHEMBL14222462 | 0.87 | ALDH1A1 (0.36) | MAP2K1NPC1ALDH1A1S1PR3CSF1R | |
| SCHEMBL14219689 | 0.85 | DHODH (0.39) | MAP2K1EGFRNPC1ALDH1A1S1PR3 | |
| SCHEMBL14220129 | 0.85 | MAP2K1 (0.36) | MAP2K1PTGS2MAP2K2SMC2EGFR | |
| SCHEMBL14223218 | 0.84 | MAP2K1 (0.48) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |