Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 8/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219621 | 0.88 | MAP2K1 (0.48) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219608 | 0.86 | DHODH (0.54) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14222530 | 0.86 | NPC1 (0.40) | MAP2K1DHODHNPC1ALDH1A1LMNA | |
| SCHEMBL14219680 | 0.85 | MAP2K1 (0.55) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14220139 | 0.84 | NPC1 (0.38) | MAP2K1DHODHNPC1ALDH1A1LMNA | |
| SCHEMBL14223198 | 0.83 | MAP2K1 (0.46) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219682 | 0.82 | MAP2K1 (0.44) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219689 | 0.82 | DHODH (0.39) | MAP2K1DHODHNPC1ALDH1A1LMNA | |
| SCHEMBL14219811 | 0.81 | MAP2K1 (0.44) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14220152 | 0.81 | MAP2K1 (0.63) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |