Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 6/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219621 | 0.84 | MAP2K1 (0.48) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219608 | 0.83 | DHODH (0.54) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219680 | 0.82 | MAP2K1 (0.55) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219679 | 0.82 | MAP2K1 (0.46) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL4731583 | 0.76 | DHODH (0.56) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14220140 | 0.75 | MAP2K1 (0.51) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14223198 | 0.75 | MAP2K1 (0.46) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14219811 | 0.74 | MAP2K1 (0.44) | MAP2K1MAP2K2DHODHLMNAGAA | |
| SCHEMBL14220138 | 0.74 | HTT (0.37) | MAP2K1DHODHIRAK4 | |
| SCHEMBL4595156 | 0.73 | DHODH (0.56) | MAP2K1MAP2K2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |