Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 5/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14220144 | 0.92 | HTT (0.38) | HTTDHODHMAP2K1IRAK4 | |
| SCHEMBL14219609 | 0.89 | DHODH (0.37) | HTTDHODHIRAK4 | |
| SCHEMBL14222532 | 0.82 | DHODH (0.44) | HTTDHODHMAP2K1 | |
| SCHEMBL14220180 | 0.79 | MAP2K1 (0.51) | MAP2K1IRAK4 | |
| SCHEMBL14219822 | 0.75 | DHODH (0.38) | DHODHMAP2K1 | |
| SCHEMBL14219693 | 0.75 | DHODH (0.41) | DHODHMAP2K1IRAK4 | |
| SCHEMBL14222530 | 0.75 | NPC1 (0.40) | DHODHMAP2K1 | |
| SCHEMBL14219682 | 0.74 | MAP2K1 (0.44) | DHODHMAP2K1IRAK4 | |
| SCHEMBL14219814 | 0.73 | DHODH (0.43) | DHODHMAP2K1 | |
| SCHEMBL14219820 | 0.72 | DHODH (0.40) | DHODHMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |