Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219822 | 0.91 | DHODH (0.38) | DHODHKDM4EASPHKDM8MAP2K1 | |
| SCHEMBL14219693 | 0.88 | DHODH (0.41) | DHODHKDM4EASPHKDM8MAP2K1 | |
| SCHEMBL14219691 | 0.84 | DHODH (0.44) | DHODHKDM4EASPHKDM8MAP2K1 | |
| SCHEMBL14220140 | 0.81 | MAP2K1 (0.51) | DHODHKDM4EASPHKDM8MAP2K1 | |
| SCHEMBL14219814 | 0.81 | DHODH (0.43) | DHODHKDM4EMAP2K1 | |
| SCHEMBL14220139 | 0.80 | NPC1 (0.38) | DHODHMAP2K1 | |
| SCHEMBL14219820 | 0.80 | DHODH (0.40) | DHODHKDM4EASPHKDM8MAP2K1 | |
| SCHEMBL14220102 | 0.78 | MAP2K1 (0.48) | DHODHKDM4EASPHKDM8MAP2K1 | |
| SCHEMBL14220144 | 0.78 | HTT (0.38) | DHODHMAP2K1IRAK4 | |
| SCHEMBL14220106 | 0.78 | DHODH (0.46) | DHODHMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |