Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 9/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222837 | 0.89 | DHODH (0.54) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14220140 | 0.88 | MAP2K1 (0.51) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL14223198 | 0.88 | MAP2K1 (0.46) | MAP2K1MAP2K2DHODHKDM4E | |
| SCHEMBL14222835 | 0.85 | MAP2K1 (0.48) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL14219822 | 0.84 | DHODH (0.38) | MAP2K1MAP2K2DHODHAURKAMAPK8 | |
| SCHEMBL14219820 | 0.81 | DHODH (0.40) | MAP2K1DHODHKDM4EASPHKDM8 | |
| SCHEMBL14219811 | 0.81 | MAP2K1 (0.44) | MAP2K1MAP2K2DHODHMAPK8KDM4E | |
| SCHEMBL14219679 | 0.80 | MAP2K1 (0.46) | MAP2K1MAP2K2DHODH | |
| SCHEMBL4595156 | 0.78 | DHODH (0.56) | MAP2K1MAP2K2DHODH | |
| SCHEMBL14219677 | 0.78 | DHODH (0.39) | MAP2K1MAP2K2DHODHAURKAMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |