Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11391402 | 0.85 | IAPP (0.45) | GABRA1GABRB2CYSLTR2CYSLTR1SLC6A2 | |
| SCHEMBL4601974 | 0.84 | CYSLTR2 (0.50) | CYSLTR2CYSLTR1 | |
| SCHEMBL4601904 | 0.82 | SMN1; SMN2 (0.40) | GABRA1GABRB2CYSLTR2CYSLTR1SLC6A2 | |
| SCHEMBL27850986 | 0.81 | IAPP (0.54) | GABRA1GABRB2CYSLTR2CYSLTR1SLC6A2 | |
| SCHEMBL27613400 | 0.78 | ALDH1A1 (0.48) | LPAR1LMNAKMT2AHPGDTSHR | |
| SCHEMBL14613770 | 0.78 | LPAR1 (0.38) | GABRA1GABRB2CYSLTR2CYSLTR1SLC6A2 | |
| SCHEMBL9839884 | 0.78 | GABRA1 (0.48) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14441154 | 0.77 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1SLC6A3SMN1; SMN2CYP1A2 | |
| SCHEMBL6055136 | 0.75 | GABRA1 (0.48) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30606846 | 0.75 | GABRA1 (0.48) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272516-B1 | SELECTIVE LINEAR PEPTIDES WITH MELANOCORTIN-4 RECEPTOR (MC4-R) AGONIST ACTIVITY | HOFFMANN LA ROCHE (CH) | 2008-04-23 | — | — | EP | disclosed |