Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13786439 | 0.93 | MAOB (0.46) | MAOBHPGDGAAALDH1A1LMNA | |
| SCHEMBL14221547 | 0.88 | GAA (0.47) | MAOBGAAALDH1A1LMNAMAPT | |
| SCHEMBL13971180 | 0.86 | HPGD (0.45) | MAOBHPGDCCR5GAAALDH1A1 | |
| SCHEMBL13971346 | 0.85 | HPGD (0.44) | MAOBHPGDCCR5GAAALDH1A1 | |
| SCHEMBL14206353 | 0.85 | GAA (0.46) | MAOBHPGDCCR5GAAALDH1A1 | |
| SCHEMBL13971076 | 0.82 | GAA (0.46) | MAOBHPGDCCR5GAAALDH1A1 | |
| SCHEMBL1878476 | 0.81 | HPGD (0.50) | MAOBHPGDGAAALDH1A1LMNA | |
| SCHEMBL14204715 | 0.80 | DHODH (0.43) | MAOBGAAALDH1A1LMNAMAPT | |
| SCHEMBL13786667 | 0.80 | ALDH1A1 (0.48) | MAOBGAAALDH1A1LMNAMAPT | |
| SCHEMBL13786603 | 0.78 | MAOB (0.53) | MAOBHPGDGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |