Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PIR | O00625 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215366 | 0.91 | LMNA (0.43) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL215871 | 0.88 | LMNA (0.43) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL3327359 | 0.88 | LMNA (0.43) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL216395 | 0.85 | ACHE (0.47) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL14222351 | 0.85 | ACHE (0.47) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL215460 | 0.82 | LMNA (0.46) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL214860 | 0.81 | LMNA (0.45) | LMNAMAPK1HIF1AACHEKDR | |
| SCHEMBL216099 | 0.81 | MAPT (0.39) | LMNAMAPK1HIF1AKDRALDH1A1 | |
| SCHEMBL213924 | 0.81 | ALDH1A1 (0.40) | LMNACHEK2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL213711 | 0.81 | ALDH1A1 (0.38) | LMNAMAPK1HIF1AKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |