Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 4/20 | 0.46 |
| ▸ | BCL2 | P10415 | 4/20 | 0.45 |
| ▸ | BAX | Q07812 | 4/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224258 | 0.97 | MAPT (0.50) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224257 | 0.88 | MAPT (0.54) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224479 | 0.87 | PTGER4 (0.57) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224475 | 0.86 | MAPT (0.58) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224468 | 0.84 | KDM4E (0.47) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224481 | 0.84 | PDE3B (0.49) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224259 | 0.83 | ITGB2 (0.60) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL14224482 | 0.82 | MEN1 (0.57) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224474 | 0.82 | MAPT (0.58) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14224476 | 0.80 | KDM4E (0.46) | MAPTRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |