Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224257 | 0.86 | MAPT (0.54) | MAPTRAB9ANPC1GAAMAPK1 | |
| SCHEMBL14224256 | 0.86 | MAPT (0.52) | MAPTRAB9ANPC1GAAMAPK1 | |
| SCHEMBL14224474 | 0.85 | MAPT (0.58) | MAPTRAB9ANPC1GAAMAPK1 | |
| SCHEMBL14224481 | 0.85 | PDE3B (0.49) | MAPTRAB9ANPC1GAAMAPK1 | |
| SCHEMBL14224259 | 0.84 | ITGB2 (0.60) | MAPTGAAITGB2ICAM1ITGAL | |
| SCHEMBL14224258 | 0.84 | MAPT (0.50) | MAPTRAB9ANPC1GAAMAPK1 | |
| SCHEMBL14224479 | 0.83 | PTGER4 (0.57) | MAPTRAB9ANPC1SMN1; SMN2ITGB2 | |
| SCHEMBL14224482 | 0.83 | MEN1 (0.57) | MAPTRAB9ANPC1GAAPDE3B | |
| SCHEMBL4821930 | 0.81 | KDM4E (0.58) | MAPTRAB9ANPC1GAAMAPK1 | |
| SCHEMBL12875511 | 0.77 | KDM4E (0.64) | MAPTRAB9ANPC1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |