Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | EIF4E | P06730 | 6/20 | 0.46 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224257 | 0.87 | MAPT (0.54) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14224475 | 0.85 | MAPT (0.58) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14224479 | 0.84 | PTGER4 (0.57) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14224258 | 0.82 | MAPT (0.50) | MAPTMEN1KMT2AARNPC1 | |
| SCHEMBL14224256 | 0.82 | MAPT (0.52) | MAPTMEN1KMT2AARNPC1 | |
| SCHEMBL1198595 | 0.81 | MEN1 (0.72) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12875608 | 0.80 | MEN1 (0.62) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12875612 | 0.80 | MAPT (0.58) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14224468 | 0.80 | KDM4E (0.47) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14224481 | 0.79 | PDE3B (0.49) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |