Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224475 | 0.85 | MAPT (0.58) | PDE3BPDE3AMAPTALDH1A1MAPK1 | |
| SCHEMBL14224256 | 0.84 | MAPT (0.52) | MAPTALDH1A1LMNAMAPK1HSD17B10 | |
| SCHEMBL14224479 | 0.84 | PTGER4 (0.57) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14224259 | 0.82 | ITGB2 (0.60) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL14196464 | 0.82 | MEN1 (0.57) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL14224258 | 0.82 | MAPT (0.50) | MAPTALDH1A1LMNAMAPK1HSD17B10 | |
| SCHEMBL6330203 | 0.81 | PDE3B (0.44) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL14224482 | 0.81 | MEN1 (0.57) | PDE3BPDE3AMAPTALDH1A1LMNA | |
| SCHEMBL14224474 | 0.79 | MAPT (0.58) | MAPTMAPK1MEN1KMT2ANPC1 | |
| SCHEMBL14224257 | 0.78 | MAPT (0.54) | PDE3BPDE3AMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |