SCHEMBL1422429

SCHEMBL1422429

c1[nH]nnc1-c1csnn1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.39
RAB9A P51151 4/20 0.39
MEN1 O00255 2/20 0.39
NPC1 O15118 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
POLB P06746 2/20 0.39
NOTUM Q6P988 1/20 0.39
LMNA P02545 1/20 0.37
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
HPGD P15428 1/20 0.35
CYP2C19 P33261 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MAPT P10636 2/20 0.31
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL87533 0.78
SCHEMBL1624105 0.78 KMT2A (0.54) KMT2ARAB9AMEN1NPC1SMN1; SMN2
SCHEMBL653484 0.67 NPC1 (0.43) KMT2ARAB9AMEN1NPC1SMN1; SMN2
SCHEMBL16678331 0.67 KMT2A (0.37) KMT2ARAB9AMEN1NPC1SMN1; SMN2
SCHEMBL1667738 0.67
SCHEMBL1015226 0.65 KMT2A (0.36) KMT2ARAB9AMEN1NPC1SMN1; SMN2
SCHEMBL20523585 0.65
SCHEMBL13078874 0.64 METAP2 (0.32) RAB9ANPC1SMN1; SMN2
SCHEMBL445070 0.64 KMT2A (0.38) KMT2ARAB9AMEN1NPC1SMN1; SMN2
SCHEMBL8617410 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117264179-B Electrochromic polymer capable of covering visible light and near infrared broadband absorption, preparation method, film and application thereof 中国人民解放军军事科学院系统工程研究院 2024-06-18 CN claimed
CN-117264179-A Electrochromic polymer capable of covering visible light and near infrared broadband absorption, preparation method, film and application thereof 中国人民解放军军事科学院系统工程研究院 2023-12-22 CN claimed
CN-116874747-A Electrochromic polymer, preparation method thereof and electrochromic polymer film 上海戎科特种装备有限公司 2023-10-13 CN claimed
US-20130231335-A1 INHIBITORS OF POLO-LIKE KINASE ELAN PHARMACEUTICALS, INC. (US) 2013-09-05 US claimed
JP-2011506281-A 2011-03-03 JP claimed
EP-2262794-A1 SULFONAMIDE COMPOUNDS AND THEIR USE AS FUNGICIDE BASF SE (DE) 2010-12-22 EP claimed
EP-2231605-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2010-09-29 EP claimed
WO-2009103650-A1 SULFONAMIDE COMPOUNDS AND THEIR USE AS FUNGICIDE BASF SE (DE) 2009-08-27 WO claimed
WO-2009071448-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO claimed
WO-2009071449-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO claimed
US-20070219197-A1 Pyridyl alkene and pyridyl alkine- acid amides as cytostatics and immuno-suppressives ASTELLAS PHARMA GMBH (DE) 2007-09-20 US claimed
EP-0579221-A1 Cephem compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-01-19 EP claimed
CN-117264179-B Electrochromic polymer capable of covering visible light and near infrared broadband absorption, preparation method, film and application thereof 中国人民解放军军事科学院系统工程研究院 2024-06-18 CN disclosed
CN-117264179-B Electrochromic polymer capable of covering visible light and near infrared broadband absorption, preparation method, film and application thereof 中国人民解放军军事科学院系统工程研究院 2024-06-18 CN disclosed
CN-117264179-A Electrochromic polymer capable of covering visible light and near infrared broadband absorption, preparation method, film and application thereof 中国人民解放军军事科学院系统工程研究院 2023-12-22 CN disclosed
CN-116874747-A Electrochromic polymer, preparation method thereof and electrochromic polymer film 上海戎科特种装备有限公司 2023-10-13 CN disclosed
US-6048878-A Substituted piperidine derivatives as selective agonists of 5-HT receptors MERCK SHARP & DOHME LTD. (GB) 2000-04-11 US disclosed
EP-0195947-A2 Beta-lactam antibiotics, process for their preparation and their use as and in medicaments BAYER AG (DE) 1986-10-01 EP disclosed
EP-0138187-A2 Photopolymerizable composition MITSUBISHI KASEI CORPORATION (JP) 1985-04-24 EP disclosed
EP-0005785-A1 Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their use HOECHST AKTIENGESELLSCHAFT (DE) 1979-12-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219197-A1 Pyridyl alkene and pyridyl alkine- acid amides as cytostatics and immuno-suppressives NFATC1, PDCD1, ACIN1 KMT2A 2317/4885RAB9A 4117/4885MEN1 2546/4885
US-20130231335-A1 INHIBITORS OF POLO-LIKE KINASE POLK, PLK1, POLR2E KMT2A 1580/4885RAB9A 1681/4885MEN1 4103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.