Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197102 | 0.82 | TP53 (0.49) | LMNATP53KMT2AALDH1A1P2RX7 | |
| SCHEMBL14224512 | 0.81 | KMT2A (0.49) | LMNAKMT2AALDH1A1P2RX7ERCC1 | |
| SCHEMBL5767472 | 0.80 | NPC1 (0.62) | LMNAKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14224513 | 0.77 | KMT2A (0.43) | LMNAKMT2AALDH1A1P2RX7ERCC1 | |
| SCHEMBL18251699 | 0.77 | ALDH1A1 (0.48) | LMNAKMT2AALDH1A1P2RX7ERCC1 | |
| SCHEMBL14679143 | 0.74 | KMT2A (0.57) | LMNAKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13384660 | 0.73 | MMP13 (0.54) | LMNATP53KMT2AALDH1A1MEN1 | |
| SCHEMBL14224777 | 0.70 | GAA (0.49) | KMT2AALDH1A1P2RX7SMN1; SMN2NPC1 | |
| SCHEMBL24776466 | 0.70 | SLC6A4 (0.50) | ALDH1A1KDM4E | |
| SCHEMBL30435098 | 0.70 | SLC6A4 (0.50) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |