Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 10/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | PKM | P14618 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224532 | 0.85 | NPC1 (0.60) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL14224796 | 0.81 | AURKA (0.48) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL14224799 | 0.78 | KDM4E (0.38) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL2293308 | 0.78 | KDM4E (1.00) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL16404989 | 0.77 | NPC1 (0.62) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL23745062 | 0.76 | RAB9A (0.51) | RAB9AMAPTMEN1KMT2APOLB | |
| SCHEMBL3336160 | 0.75 | NPC1 (0.63) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL19753886 | 0.74 | NPC1 (0.54) | NPC1KDM4ENPSR1RECQLRAB9A | |
| SCHEMBL24630455 | 0.74 | RAB9A (0.56) | NPC1KDM4ERECQLRAB9ASMN1; SMN2 | |
| SCHEMBL15786288 | 0.73 | SMN1; SMN2 (0.65) | NPC1KDM4ENPSR1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090816-A1 | ANTI-INFECTIVE BIARYL COMPOUNDS | GENESOFT PHARMACEUTICALS, INC. (US) | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090816-A1 | ANTI-INFECTIVE BIARYL COMPOUNDS | QTRT1, Q6ZSR9, QTRT2 | NPC1 796/4885KDM4E 3096/4885NPSR1 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.