Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126961 | 0.94 | CYP1A2 (0.50) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| SCHEMBL27684835 | 0.93 | PDE5A (0.50) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| Hydrochloric Acid SCHEMBL28282489 | 0.91 | PDE5A (0.49) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| SCHEMBL6655861 | 0.90 | CHRNB2 (0.51) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| Formaldehyde SCHEMBL27812370 | 0.85 | GRM5 (0.48) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| SCHEMBL7245296 | 0.85 | CHRNB2 (0.46) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| SCHEMBL19342481 | 0.84 | CHRNB2 (0.47) | CYP2C19CYP2C9CYP1A2PDE5APDE4A | |
| SCHEMBL8325639 | 0.82 | ALDH1A1 (0.52) | PDE5ACHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL31461865 | 0.82 | ALDH1A1 (0.52) | PDE5ACHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL1536664 | 0.81 | NCF1 (0.48) | CYP2C19CYP2C9CYP1A2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690281-A | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2018-02-13 | — | — | CN | disclosed |
| US-7354946-B2 | prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-08 | — | — | US | disclosed |
| US-20070027147-A1 | Biarylurea derivatives | MSD K.K. (JP) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027147-A1 | Biarylurea derivatives | CDK6, CDK4, CCNI | CYP2C19 759/4885CYP2C9 1010/4885CYP1A2 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.