Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | YWHAG | P61981 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14226837 | 0.84 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL14226901 | 0.81 | KDM4E (0.58) | ALDH1A1SMN1; SMN2KDM4EGAAPOLB | |
| SCHEMBL29930952 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL11167415 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL6644223 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL23611740 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL11163688 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL11610621 | 0.80 | HTT (0.77) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL6254176 | 0.80 | HTT (0.77) | ALDH1A1SMN1; SMN2KDM4EPKMGAA | |
| SCHEMBL6643354 | 0.78 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090822-A1 | Piperazine Derivatives As Glyt 1 Inhibitors | GLAXO GROUP LIMITED | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090822-A1 | Piperazine Derivatives As Glyt 1 Inhibitors | SLC6A7, SLC6A5, SLC1A2 | ALDH1A1 1381/4885SMN1; SMN2 3532/4885KDM4E 2626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.