Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 15/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422691 | 0.83 | HTR6 (0.59) | ACLYHTR6HTR2CCYP3A4 | |
| SCHEMBL338189 | 0.75 | HTR6 (0.69) | ACLYHTR6HTR2CCCKBR | |
| SCHEMBL1422633 | 0.75 | ACLY (0.58) | ACLYHTR6HTR2CCCKBRPKM | |
| SCHEMBL1423219 | 0.73 | ACLY (0.56) | ACLYHTR6HTR2CHTR7CYP3A4 | |
| SCHEMBL3142915 | 0.73 | HTR6 (0.67) | ACLYHTR6HTR2CCCKBR | |
| SCHEMBL10240490 | 0.73 | ACLY (0.47) | ACLYHTR6HTR2CCCKBR | |
| SCHEMBL1423370 | 0.73 | ACLY (0.53) | ACLYHTR6CCKBRPKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9958746 | 0.72 | ACLY (0.47) | ACLYHTR6HTR2CCCKBR | |
| SCHEMBL1423218 | 0.71 | ACLY (0.54) | ACLYHTR6HTR2CADRA2ACCKBR | |
| SCHEMBL3261001 | 0.71 | HTR6 (0.67) | ACLYHTR6HTR2CADRA2ACCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297166-A1 | SUBSTITUTED N-IMIDAZO[2,1-B]THIAZOLE-5-SULFONAMIDE DERIVATIVES AS 5-HT6 LIGANDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-03-23 | — | — | EP | claimed |