Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641991 | 0.88 | KDM4E (0.69) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL29459607 | 0.86 | RAB9A (0.67) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL11219138 | 0.86 | RAB9A (0.67) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL11574839 | 0.84 | NPC1 (0.61) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL867138 | 0.83 | RAB9A (0.81) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL30932699 | 0.83 | RAB9A (0.81) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL11574062 | 0.81 | RAB9A (0.63) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL1307242 | 0.81 | PPARG (0.81) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL17774882 | 0.79 | KCNMA1 (0.61) | RAB9ANPC1KDM4EALDH1A1MAPT | |
| SCHEMBL1308769 | 0.79 | PPARG (0.69) | RAB9ANPC1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638556-B1 | 2-AMINOBENZOTHIAZOLES AS CB1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | EP | disclosed |