Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229211 | 0.91 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4ELMNAUSP2 | |
| SCHEMBL14230158 | 0.89 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4ELMNAUSP2 | |
| SCHEMBL14229215 | 0.88 | ALDH1A1 (0.41) | ALDH1A1TSHRKDM4ELMNAUSP2 | |
| SCHEMBL14229554 | 0.85 | MEN1 (0.35) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL14229693 | 0.85 | ALDH1A1 (0.45) | ALDH1A1TSHRKDM4ELMNAUSP2 | |
| SCHEMBL14229219 | 0.85 | MEN1 (0.35) | KMT2AMEN1 | |
| SCHEMBL14200487 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4ELMNAUSP2 | |
| SCHEMBL14229265 | 0.84 | CYP1A2 (0.39) | ALDH1A1TSHRKDM4EKMT2AMEN1 | |
| SCHEMBL14229456 | 0.83 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4ELMNAUSP2 | |
| SCHEMBL14229025 | 0.81 | ALDH1A1 (0.42) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |