Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229525 | 0.95 | CNR2 (0.38) | BMP1CNR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14229340 | 0.93 | CNR2 (0.40) | BMP1CNR2CA1CA2CA9 | |
| SCHEMBL14229023 | 0.90 | BMP1 (0.36) | BMP1CNR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14229109 | 0.89 | BMP1 (0.40) | BMP1CNR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14229012 | 0.86 | CNR2 (0.46) | BMP1CNR2MAPK1MMP1MMP2 | |
| SCHEMBL14229914 | 0.85 | CA1 (0.40) | BMP1CNR2MAPK1MMP1MMP2 | |
| SCHEMBL14200415 | 0.85 | BMP1 (0.35) | BMP1CNR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14230123 | 0.85 | PIK3CD (0.37) | BMP1CNR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14229348 | 0.84 | BMP1 (0.32) | BMP1CYP1A2CYP3A4CYP2C9PKM | |
| SCHEMBL14230189 | 0.82 | CA1 (0.48) | BMP1CNR2MAPK1MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |