Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229217 | 0.88 | AGTR1 (0.42) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL14200751 | 0.86 | HPGD (0.37) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL14228959 | 0.79 | AGTR1 (0.54) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL14228976 | 0.77 | AGTR1 (0.53) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL14229890 | 0.75 | ALDH1A1 (0.40) | AGTR1AGTR2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL14200700 | 0.75 | HPGD (0.35) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL14200875 | 0.72 | AGTR1 (0.48) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL5200518 | 0.70 | KCNMA1 (0.47) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL30540817 | 0.69 | HPGD (0.44) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL12125020 | 0.68 | HPGD (0.43) | AGTR1AGTR2HPGDALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |