Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2162340 | 0.95 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTUBE2NCYP19A1 | |
| SCHEMBL1423438 | 0.88 | ALDH1A1 (0.39) | ALDH1A1LMNAHTTUBE2NCYP19A1 | |
| SCHEMBL1421817 | 0.88 | AR (0.36) | ALDH1A1CYP19A1HDAC3HDAC4HDAC1 | |
| SCHEMBL12397642 | 0.87 | GAA (0.39) | ALDH1A1LMNAHTTUBE2NCYP19A1 | |
| SCHEMBL1423259 | 0.85 | CYP19A1 (0.37) | CYP19A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1423209 | 0.85 | DYRK1A (0.40) | CYP19A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1423530 | 0.85 | ALDH1A1 (0.40) | ALDH1A1LMNAHTTUBE2NCYP19A1 | |
| SCHEMBL1349164 | 0.84 | CYP19A1 (0.32) | CYP19A1MC4RMC5RMC3R | |
| SCHEMBL1349693 | 0.84 | CYP19A1 (0.35) | CYP19A1CYP2D6SLC6A2SLC6A4KCNH2 | |
| SCHEMBL2161190 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNAHTTUBE2NHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183928-A1 | 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-28 | — | — | US | disclosed |
| EP-2297099-A1 | 3-CYANOALKYL- AND 3-HYDROXYALKYLINDOLES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009156091-A1 | 3-CYANOALKYL- AND 3-HYDROXYALKYLINDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009156091-A1 | 3-CYANOALKYL- AND 3-HYDROXYALKYLINDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183928-A1 | 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof | HTR3C, HTR3A, ADRB3 | ALDH1A1 813/4885LMNA 520/4885HTT 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.