Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | KDM5A | P29375 | 3/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | PPARD | Q03181 | 4/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229461 | 0.93 | EPHX2 (0.46) | EPHX2CES2CES1KDM5APHF8 | |
| SCHEMBL14228986 | 0.93 | EPHX2 (0.38) | EPHX2CA2CES2CES1KDM5A | |
| SCHEMBL14228999 | 0.89 | EPHX2 (0.36) | EPHX2CA2CES2CES1KDM5A | |
| SCHEMBL14229257 | 0.87 | EPHX2 (0.47) | EPHX2CES2CES1KDM5APHF8 | |
| SCHEMBL14229425 | 0.86 | ALDH1A1 (0.35) | EPHX2CA2CES2CES1TSHR | |
| SCHEMBL14229901 | 0.85 | EPHX2 (0.38) | EPHX2CES2CES1KDM5APHF8 | |
| SCHEMBL27426565 | 0.85 | DNM1 (0.44) | EPHX2DNM1KDM5APHF8KDM4C | |
| SCHEMBL25962151 | 0.85 | DNM1 (0.44) | EPHX2DNM1KDM5APHF8KDM4C | |
| SCHEMBL22208603 | 0.83 | DNM1 (0.47) | EPHX2DNM1KDM5APHF8KDM4C | |
| SCHEMBL25964213 | 0.83 | DNM1 (0.47) | EPHX2DNM1KDM5APHF8KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |