Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.62 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.56 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.56 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.56 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.56 |
| ▸ | BMP1 | P13497 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13979922 | 0.97 | CNR2 (0.61) | TAS2R14CNR2SMN1; SMN2CA12CA9 | |
| SCHEMBL14200189 | 0.87 | TAS2R14 (0.56) | TAS2R14CNR2SMN1; SMN2CA12CA9 | |
| SCHEMBL14200203 | 0.87 | CNR2 (0.53) | TAS2R14CNR2SMN1; SMN2RAB9ABMP1 | |
| SCHEMBL6324195 | 0.87 | SMN1; SMN2 (0.65) | TAS2R14CNR2SMN1; SMN2CA9RAB9A | |
| SCHEMBL31337910 | 0.87 | TAS2R14 (0.69) | TAS2R14SMN1; SMN2CA12CA9RAB9A | |
| SCHEMBL6325862 | 0.85 | BMP1 (0.63) | TAS2R14CNR2SMN1; SMN2CA9RAB9A | |
| SCHEMBL6323753 | 0.84 | CNR2 (0.53) | TAS2R14CNR2BMP1MMP1MMP7 | |
| SCHEMBL14261130 | 0.84 | TAS2R14 (0.55) | TAS2R14CNR2SMN1; SMN2CA12CA9 | |
| SCHEMBL14201255 | 0.84 | TAS2R14 (0.55) | TAS2R14CNR2SMN1; SMN2CA12CA9 | |
| SCHEMBL6323499 | 0.83 | MMP13 (0.52) | TAS2R14CNR2BMP1MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |