Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP2 | O95551 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299377 | 0.86 | PGR (0.56) | ALDH1A1PGRMAPTMEN1KMT2A | |
| SCHEMBL5869157 | 0.86 | — | — | |
| SCHEMBL5869053 | 0.83 | PGR (0.58) | PGRTDP2GRM2 | |
| SCHEMBL5868936 | 0.83 | CYP3A4 (0.62) | PGRRAB9ASMN1; SMN2TDP2 | |
| SCHEMBL14744813 | 0.81 | GRM2 (0.50) | ALDH1A1PGRRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1420797 | 0.80 | ALDH1A1 (1.00) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL1423439 | 0.80 | ALDH1A1 (0.72) | ALDH1A1PGRRAB9ASMN1; SMN2TP53 | |
| SCHEMBL1424406 | 0.80 | ALDH1A1 (0.72) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL2301504 | 0.80 | ALDH1A1 (0.72) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL1423287 | 0.79 | MAPT (0.48) | ALDH1A1PGRMAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083355-A1 | COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2016-03-24 | — | — | US | claimed |
| US-20140073633-A1 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT. (FR) | 2014-03-13 | — | — | US | claimed |
| US-20120283249-A1 | Novel compounds which have a protective activity with respect to the action of toxins and of viruses with an intracellular mode of action | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2012-11-08 | — | — | US | claimed |
| US-20110201601-A1 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | COMMISSAR. A L'ENERG. ATOM. ET AUX ENERG. ALTERN. (FR) | 2011-08-18 | — | — | US | claimed |
| EP-2296757-A2 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR) | 2011-03-23 | — | — | EP | claimed |
| EP-2145873-A1 | New compounds with activity that protects against the action of toxins and viruses in intracellular action mode | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2010-01-20 | — | — | EP | claimed |
| WO-2009153665-A2 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2009-12-23 | — | — | WO | claimed |
| EP-3239131-A1 | NEW COMPOUNDS WITH ACTIVITY THAT PROTECTS AGAINST THE ACTION OF TOXINS AND VIRUSES IN INTRACELLULAR ACTION MODE | Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) | 2017-11-01 | — | — | EP | disclosed |
| US-20170233386-A1 | Compounds Which Have a Protective Activity with Respect to the Action of Toxins and of Viruses with an Intracellular Mode of Action | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2017-08-17 | — | — | US | disclosed |
| US-20170233386-A1 | Compounds Which Have a Protective Activity with Respect to the Action of Toxins and of Viruses with an Intracellular Mode of Action | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2017-08-17 | — | — | US | disclosed |
| US-20160083355-A1 | COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2016-03-24 | — | — | US | disclosed |
| US-9034868-B2 | Inhibitors of the shiga toxins trafficking through the retrograde pathway | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2015-05-19 | — | — | US | disclosed |
| US-20140073633-A1 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT. (FR) | 2014-03-13 | — | — | US | disclosed |
| US-8609732-B2 | Inhibitors of the Shiga toxins trafficking through the retrograde pathway | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2013-12-17 | — | — | US | disclosed |
| WO-2013123217-A1 | SMALL MOLECULES THAT ENHANCE THE ACTIVITY OF OLIGONUCLEOTIDES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2013-08-22 | — | — | WO | disclosed |
| US-20120283249-A1 | Novel compounds which have a protective activity with respect to the action of toxins and of viruses with an intracellular mode of action | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2012-11-08 | — | — | US | disclosed |
| US-20110201601-A1 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | COMMISSAR. A L'ENERG. ATOM. ET AUX ENERG. ALTERN. (FR) | 2011-08-18 | — | — | US | disclosed |
| EP-2145873-A1 | New compounds with activity that protects against the action of toxins and viruses in intracellular action mode | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2010-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283249-A1 | Novel compounds which have a protective activity with respect to the action of toxins and of viruses with an intracellular mode of action | HAVCR2, MAVS, ANTXR2 | ALDH1A1 4453/4885PGR 3753/4885MAPT 1849/4885 |
| US-20140073633-A1 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | SLC47A2, GOLT1B, SLC47A1 | ALDH1A1 3673/4885PGR 4544/4885MAPT 1756/4885 |
| US-20160083355-A1 | COMPOUNDS WHICH HAVE A PROTECTIVE ACTIVITY WITH RESPECT TO THE ACTION OF TOXINS AND OF VIRUSES WITH AN INTRACELLULAR MODE OF ACTION | HAVCR2, MAVS, ANTXR2 | ALDH1A1 4539/4885PGR 3375/4885MAPT 1644/4885 |
| US-20170233386-A1 | Compounds Which Have a Protective Activity with Respect to the Action of Toxins and of Viruses with an Intracellular Mode of Action | HAVCR2, MAVS, ANTXR2 | ALDH1A1 4539/4885PGR 3375/4885MAPT 1644/4885 |
| US-20110201601-A1 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY | SLC47A2, GOLT1B, SLC47A1 | ALDH1A1 3673/4885PGR 4544/4885MAPT 1756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.