Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | DNM2 | P50570 | 2/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230204 | 0.96 | MAPT (0.35) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL5676042 | 0.91 | AGTR1 (0.35) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL14200647 | 0.88 | HTT (0.31) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL14230156 | 0.86 | SMN1; SMN2 (0.35) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL14229720 | 0.86 | NFKB1 (0.41) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL14229191 | 0.83 | SMN1; SMN2 (0.37) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL14229386 | 0.83 | NFKB1 (0.39) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL7254985 | 0.80 | GBA1 (0.40) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL18924521 | 0.79 | CRHR1 (0.33) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL13969515 | 0.79 | TDP1 (0.41) | SMN1; SMN2TSHRMAPTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |