Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA9 | Q16790 | 5/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA7 | P43166 | 4/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7638 | 0.79 | ALDH1A1 (0.63) | ALDH1A1SLC9A1TSHRHSD17B10MEN1 | |
| SCHEMBL473080 | 0.79 | ALDH1A1 (0.63) | ALDH1A1SLC9A1TSHRHSD17B10MEN1 | |
| SCHEMBL29405187 | 0.79 | ALDH1A1 (0.63) | ALDH1A1SLC9A1TSHRHSD17B10MEN1 | |
| SCHEMBL14044876 | 0.79 | ALDH1A1 (0.34) | ALDH1A1TSHRGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11468851 | 0.76 | ALDH1A1 (0.55) | ALDH1A1SLC9A1TSHRMEN1LMNA | |
| SCHEMBL9328343 | 0.76 | HPGD (0.52) | ALDH1A1TSHRHPGDMAPK1HSD17B10 | |
| SCHEMBL26622733 | 0.76 | ALDH1A1 (0.44) | ALDH1A1CA2CA9TSHRHPGD | |
| SCHEMBL9964995 | 0.76 | ALDH1A1 (0.44) | ALDH1A1CA2CA9TSHRMAOB | |
| SCHEMBL9562250 | 0.76 | ALDH1A1 (0.60) | ALDH1A1SLC9A1TSHRHPGDMAPK1 | |
| SCHEMBL22496001 | 0.76 | ALDH1A1 (0.60) | ALDH1A1SLC9A1TSHRHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057133-B1 | DI-AMINO-SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| EP-1716150-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2008011110-A2 | DI-AMINO-SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2008-01-24 | — | — | WO | disclosed |