Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633493 | 0.85 | DRD2 (0.41) | DRD2HTR1AHTR7HTR6DRD1 | |
| SCHEMBL13633485 | 0.84 | DRD2 (0.47) | DRD2HTR1AHTR7HTR6DRD1 | |
| SCHEMBL13633465 | 0.84 | HTR1A (0.51) | DRD2HTR1AHTR7DRD1DRD3 | |
| SCHEMBL13633487 | 0.82 | DRD2 (0.43) | DRD2HTR1AHTR7HTR6DRD1 | |
| SCHEMBL13633434 | 0.82 | DRD2 (0.52) | DRD2HTR1AHTR7DRD1DRD3 | |
| SCHEMBL13633492 | 0.77 | DRD2 (0.45) | DRD2HTR1AHTR7DRD1DRD3 | |
| SCHEMBL13633482 | 0.77 | HTR1A (0.54) | DRD2HTR1AHTR7DRD1DRD3 | |
| SCHEMBL13633481 | 0.77 | DRD2 (0.48) | DRD2HTR1AHTR7DRD1DRD3 | |
| SCHEMBL13633483 | 0.76 | LTA4H (0.53) | DRD2HTR1AHTR7DRD1DRD3 | |
| SCHEMBL2641162 | 0.70 | HTR1A (0.43) | DRD2HTR1AHTR7DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135131-A9 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2008-04-03 | — | — | WO | disclosed |