Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | RORA | P35398 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | RORB | Q92753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14232290 | 0.89 | DHFR (0.38) | ARPGRDHFRRORARORC | |
| SCHEMBL14231569 | 0.86 | RORA (0.33) | ARPGRRORARORCRORB | |
| SCHEMBL14232282 | 0.84 | RORA (0.34) | ARPGRRORARORCRORB | |
| SCHEMBL2438861 | 0.81 | AR (0.61) | ARPGRDHFR | |
| SCHEMBL14232156 | 0.76 | RORA (0.34) | RORARORCRORB | |
| SCHEMBL14231640 | 0.75 | RORA (0.30) | RORARORCRORB | |
| SCHEMBL14231638 | 0.75 | RORA (0.30) | RORARORCRORB | |
| SCHEMBL14231637 | 0.75 | RORA (0.33) | ARRORARORCRORB | |
| SCHEMBL14231639 | 0.75 | PGR (0.31) | ARPGRRORARORCRORB | |
| SCHEMBL14232283 | 0.75 | RORA (0.31) | RORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042571-A2 | SUBSTITUTED INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-10 | — | — | WO | disclosed |