Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432412 | 0.89 | TDP1 (0.41) | KDM4EARPGRMAPTTDP1 | |
| SCHEMBL2432399 | 0.87 | MAPT (0.41) | KDM4EARPGRMAPTTDP1 | |
| SCHEMBL14231567 | 0.85 | MAPT (0.42) | KDM4EMAPTTDP1HSD17B10LMNA | |
| SCHEMBL12292683 | 0.79 | TDP1 (0.39) | KDM4EMAPTTDP1HSD17B10LMNA | |
| SCHEMBL14231566 | 0.79 | F10 (0.39) | KDM4EMAPTTDP1HSD17B10LMNA | |
| SCHEMBL15579809 | 0.77 | MAPT (0.41) | KDM4EMAPTTDP1HSD17B10LMNA | |
| SCHEMBL2433850 | 0.76 | METAP2 (0.40) | KDM4EMAPTHSD17B10LMNATSHR | |
| SCHEMBL2428544 | 0.76 | ALDH1A1 (0.42) | KDM4EMAPTTDP1HSD17B10LMNA | |
| SCHEMBL23045596 | 0.75 | NOD2 (0.46) | KDM4EHSD17B10LMNATSHRSMN1; SMN2 | |
| SCHEMBL29463231 | 0.75 | NOD2 (0.46) | KDM4EHSD17B10LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042571-A2 | SUBSTITUTED INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-10 | — | — | WO | disclosed |