Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | ACP3 | P15309 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423288 | 0.83 | CYP2C19 (0.45) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL31359426 | 0.74 | CYP2C19 (0.43) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL3755263 | 0.74 | CYP2C19 (0.43) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL19130800 | 0.73 | CYP2C19 (0.56) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL9806370 | 0.73 | CYP2C19 (0.56) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL2450375 | 0.73 | CYP2C19 (0.42) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL1424040 | 0.71 | CDC25B (0.47) | CYP2C19TSHRHPGDCYP1A2NPSR1 | |
| SCHEMBL2453942 | 0.71 | TSHR (0.44) | CYP2C19CYP3A4TSHRCFTRGOPC | |
| SCHEMBL10439558 | 0.67 | CYP1A2 (0.44) | CYP2C19CYP3A4TSHRHPGDCYP1A2 | |
| SCHEMBL17111064 | 0.67 | CYP2C19 (0.44) | CYP2C19CYP3A4TSHRCFTRGOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258167-B2 | Naphthylmethylimidizoles as therapeutic agents | ALLERGAN, INC (US) | 2012-09-04 | — | — | US | disclosed |
| US-8013169-B2 | Naphthylmethylimidizoles as therapeutic agents | ALLERGAN, INC (US) | 2011-09-06 | — | — | US | disclosed |
| EP-2296648-A1 | NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE | Allergan, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009140137-A9 | NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE | ALLERGAN, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| US-20100004305-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALLERGAN, INC. | 2010-01-07 | — | — | US | disclosed |
| WO-2009140137-A1 | NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE | ALLERGAN, INC. (US) | 2009-11-19 | — | — | WO | disclosed |
| US-20090286842-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| WO-2008086131-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286842-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | NQO1, HNMT, ALPI | CYP2C19 1231/4885CYP3A4 2623/4885TSHR 4688/4885 |
| US-20100004305-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALPI, ALPP, NCL | CYP2C19 728/4885CYP3A4 727/4885TSHR 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.