Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 7/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423435 | 0.83 | CDC25B (0.47) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL2203211 | 0.75 | CDC25B (0.49) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL643241 | 0.74 | TRPM8 (0.38) | ALDH1A1KMT2AMEN1HTTPLK1 | |
| SCHEMBL9656194 | 0.74 | CYP1B1 (0.44) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL9657375 | 0.74 | NR4A1 (0.34) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL9656211 | 0.74 | CYP1B1 (0.44) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL2203209 | 0.72 | CDC25B (0.46) | CDC25BNR4A1NR4A2NR4A3CNR2 | |
| SCHEMBL1423385 | 0.71 | CYP2C19 (0.42) | ALDH1A1HPGDKDM4ECYP1A2TSHR | |
| SCHEMBL2453942 | 0.71 | TSHR (0.44) | ALDH1A1HPGDKDM4EKMT2ACYP1A2 | |
| SCHEMBL8499951 | 0.70 | KCNN4 (0.36) | ALDH1A1HPGDKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258167-B2 | Naphthylmethylimidizoles as therapeutic agents | ALLERGAN, INC (US) | 2012-09-04 | — | — | US | disclosed |
| US-8013169-B2 | Naphthylmethylimidizoles as therapeutic agents | ALLERGAN, INC (US) | 2011-09-06 | — | — | US | disclosed |
| EP-2296648-A1 | NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE | Allergan, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009140137-A9 | NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE | ALLERGAN, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| US-20100004305-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALLERGAN, INC. | 2010-01-07 | — | — | US | disclosed |
| WO-2009140137-A1 | NAPHTHYLMETHYLIMIDIZOLES FOR THE TREATMENT OF STRESS URINARY INCONTINENCE | ALLERGAN, INC. (US) | 2009-11-19 | — | — | WO | disclosed |
| US-20090286842-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| WO-2008086131-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286842-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | NQO1, HNMT, ALPI | CDC25B 1619/4885NR4A1 2958/4885NR4A2 2595/4885 |
| US-20100004305-A1 | NAPHTHYLMETHYLIMIDIZOLES AS THERAPEUTIC AGENTS | ALPI, ALPP, NCL | CDC25B 1277/4885NR4A1 982/4885NR4A2 1204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.