Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12925721 | 0.93 | CACNA1B (0.44) | RPS6KB1AURKAPDPK1CSF1RCACNA1B | |
| SCHEMBL12341435 | 0.84 | RPS6KB1 (0.42) | RPS6KB1AURKAPDPK1AURKBCSF1R | |
| SCHEMBL12342109 | 0.82 | CSF1R (0.42) | RPS6KB1AURKACSF1RCACNA1BKIT | |
| SCHEMBL12304343 | 0.79 | CSF1R (0.43) | AURKBCSF1REPHX2KDRFLT3 | |
| SCHEMBL1267328 | 0.77 | CSF1R (0.68) | RPS6KB1AURKAPDPK1AURKBCSF1R | |
| SCHEMBL13056388 | 0.76 | CSF1R (0.52) | CSF1REPHX2KIT | |
| SCHEMBL12342164 | 0.73 | CSF1R (0.52) | RPS6KB1AURKAPDPK1AURKBCSF1R | |
| SCHEMBL12341431 | 0.73 | CSF1R (0.49) | RPS6KB1AURKAPDPK1AURKBCSF1R | |
| SCHEMBL1267604 | 0.69 | CSF1R (0.71) | RPS6KB1AURKAPDPK1AURKBCSF1R | |
| SCHEMBL24594059 | 0.69 | CSF1R (0.54) | AURKBCSF1RKDRFLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309756-A1 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON INC | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309756-A1 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | KIT, FLT3, FLT1 | RPS6KB1 619/4885AURKA 666/4885PDPK1 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.