Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.38 |
| ▸ | STK3 | Q13188 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5075075 | 0.83 | RPS6KA5 (0.41) | LATS1RPS6KA5ROCK2ROCK1CDC42BPB | |
| SCHEMBL14236575 | 0.76 | ROCK2 (0.44) | LATS1RPS6KA5ROCK2ROCK1CDC42BPB | |
| SCHEMBL14238607 | 0.71 | JAK3 (0.36) | ROCK2ROCK1CDC42BPBMARK3JAK3 | |
| SCHEMBL14327598 | 0.70 | JAK2 (0.38) | — | |
| SCHEMBL25505874 | 0.69 | LMNA (0.44) | JAK3 | |
| SCHEMBL1797434 | 0.69 | RPS6KA5 (0.42) | LATS1RPS6KA5CAMKK2BAZ2ACCNT1 | |
| SCHEMBL5635477 | 0.68 | PIM1 (0.41) | ROCK2ROCK1CDC42BPB | |
| SCHEMBL5635759 | 0.68 | PIM1 (0.41) | ROCK2ROCK1CDC42BPB | |
| SCHEMBL5635485 | 0.68 | PIM1 (0.41) | ROCK2ROCK1CDC42BPB | |
| SCHEMBL5078760 | 0.68 | CHUK (0.42) | ROCK2ROCK1FLT3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532667-A1 | Deazapurines useful as inhibitors of janus kinases | Vertex Pharmaceuticals Incorporated (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-1931674-B1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMA (US) | 2012-12-12 | — | — | EP | disclosed |