Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633718 | 0.71 | JAK2 (0.44) | JAK2 | |
| SCHEMBL14465247 | 0.71 | MEN1 (0.51) | — | |
| SCHEMBL14236254 | 0.70 | LATS1 (0.41) | — | |
| SCHEMBL14327604 | 0.69 | JAK2 (0.40) | JAK2MAPK1 | |
| SCHEMBL8943361 | 0.69 | JAK2 (0.49) | JAK2 | |
| SCHEMBL18052018 | 0.69 | JAK2 (0.44) | JAK2 | |
| SCHEMBL15998701 | 0.68 | JAK2 (0.48) | JAK2 | |
| SCHEMBL18052074 | 0.68 | — | — | |
| SCHEMBL18052006 | 0.68 | — | — | |
| SCHEMBL10304023 | 0.68 | MAP3K11 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2537849-A2 | Azaindoles useful as inhibitors of janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2012-12-26 | — | — | EP | disclosed |