Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL14237107 | 0.78 | CCR2 (0.62) | CCR2 | |
| Bicarbonate SCHEMBL14237192 | 0.78 | CCR2 (0.62) | CCR2 | |
| Bicarbonate SCHEMBL14237132 | 0.77 | CCR2 (0.44) | CCR2 | |
| Bicarbonate SCHEMBL14237273 | 0.76 | CCR2 (0.55) | CCR2MEN1KMT2AHCAR3HCAR2 | |
| Bicarbonate SCHEMBL14237102 | 0.75 | CCR2 (0.58) | CCR2HCAR2 | |
| Bicarbonate SCHEMBL14237166 | 0.74 | CCR2 (0.46) | CCR2 | |
| Bicarbonate SCHEMBL14237079 | 0.74 | CCR2 (0.47) | CCR2MEN1KMT2A | |
| SCHEMBL14237119 | 0.73 | CCR2 (1.00) | CCR2 | |
| Bicarbonate SCHEMBL14237153 | 0.73 | CCR2 (0.57) | CCR2MEN1KMT2AHCAR2 | |
| SCHEMBL14237157 | 0.70 | CCR2 (0.61) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318352-B1 | CYCLOHEXENYL COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |