Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 15/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237689 | 0.91 | GPR119 (0.37) | NPC1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14237370 | 0.86 | NPC1 (0.40) | NPC1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2542089 | 0.86 | GPR119 (0.34) | NPC1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14237714 | 0.86 | GPR6 (0.36) | GPR6 | |
| SCHEMBL14237555 | 0.84 | CHEK1 (0.34) | NPC1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14237358 | 0.84 | GPR119 (0.39) | NPC1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14237588 | 0.83 | MAPT (0.35) | NPC1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2536248 | 0.82 | GPR119 (0.44) | MCHR1 | |
| SCHEMBL14237366 | 0.81 | GPR119 (0.36) | — | |
| SCHEMBL14237295 | 0.81 | GPR119 (0.38) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |